Our publication on material-induced heterotopic ossification

Over the years, our work has centred on elucidating the mechanisms underlying material-induced heterotopic ossification (MIHO), or osteoinduction.

In our latest publication in Materials Today Bio, we investigate the combined influence of specific surface chemistry—particularly the release of acidic phosphate species—and architectural features, namely concave pore geometry, of bone graft substitutes on their ability to induce bone formation in soft tissue. Our findings highlight that while topography is important, chemistry plays an equally critical role in driving osteoinductive responses. 

Topography isn't the end all be all to MIHO/Osteoinduction, chemistry plays a significant role, and we have evidence for it. Curious? You can find the publication here.

We would like to thank Innosuisse for funding this work as part of project 52851.1 IP-LS and Nils Warfving and Ricardo de Miguel from Anapath for the excellent collaboration on the histology.